Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-07-29
1993-12-28
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514398, 514400, 5483157, 5483281, 5483285, 5483111, 5483151, A61K 31415, C07D40302, C07D40310, C07D40314
Patent
active
052739910
ABSTRACT:
The present invention relates to oligopeptide derivatives that are conjugated to DNA alkylating agents, having the formula ##STR1## wherein m is 0 to 4; n is 2 to 4; each R.sub.1 is the same or different and is hydrogen or C.sub.1 -C.sub.4 alkyl; and R is a DNA alkylating moiety. The present invention is further directed to pharmaceutical compositions thereof, and method for treatment of cancer using the subject compounds.
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Higel Floyd D.
Research Corporation Technologies Inc.
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