Imidazole containing aminoboronic acids

Details Imidazole containing aminoboronic acids Imidazole containing aminoboronic acids

1995-03-24

1997-06-17

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

514 18, 514 19, 530331, 544 60, 544 69, 544229, 546 13, 548110, A61K 3169, C07F 502, C07F 504, C07K 5065

Patent

active

056397399

ABSTRACT:
The present invention relates generally to .alpha.-aminoboronic acids and corresponding peptide analogs of the formula (I): ##STR1## in which the .alpha.-carbon is substituted with an optionally functionalized imidazole containing alkyl group. These compounds are useful as inhibitors of trypsin-like serine protease enzymes, especially thrombin, Factor X and Factor VII.

REFERENCES:
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4537773 (1985-08-01), Shenvi
patent: 5106948 (1992-04-01), Kinder et al.
patent: 5169841 (1992-12-01), Kleeman et al.
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5288707 (1994-02-01), Metternich
patent: 5332822 (1994-07-01), Misra
patent: 5444049 (1995-08-01), de Nanteuil et al.
patent: 5462964 (1995-10-01), Fevig et al.
patent: 5543526 (1996-08-01), Mallart et al.
Kettner et al, Journal of Biological Chemistry, 265, pp. 18289-18297 (190).

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