Imidazole compounds which reduce gastric acid secretion

Details Imidazole compounds which reduce gastric acid secretion Imidazole compounds which reduce gastric acid secretion

1982-12-30

1985-01-22

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544144, 544373, 546200, 548253, 548336, 548465, 548472, 514381, 514382, A61K 31415, C07D40312

Patent

active

044951930

ABSTRACT:
A compound having gastric acid secretion reducing activity and having the formula ##STR1## wherein each V and W, independently, is H, --CH.sub.2 COOR.sup.4 where R.sup.4 is H or lower alkyl, --CH.sub.2 CN, or ##STR2## or V and W together represent .dbd.CHCOOR.sup.4 or .dbd.CHCN; A is ##STR3## R.sup.1 is H or CH.sub.3 ; L is CH.sub.2 S; Q is O or CH.sub.2 S; n is 0 or 1; 2 m 4; each R.sup.2 and R.sup.3, independently, is hydrogen, lower alkyl, lower cycloalkyl, or lower aralkyl; or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 4, 5, or 6 membered heterocyclic ring containing 0, 1, or 2 oxygen atoms and 1, 2, or 3 nitrogen atoms and being unsubstituted or lower alkyl substituted; and Ar is a single ring aromatic group selected from aryl, substituted aryl, fused aryl, or heteroaryl; or the pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3987174 (1976-10-01), Cotrel et al.
patent: 4128658 (1978-12-01), Price et al.
Lumma, W., et al., J. Med. Chem. 25, 207-210 (1982).
Algieri, A., et al., J. Med. Chem. 25, 210-212 (1982).

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