Imidazole compounds and their use as transglutaminase inhibitors

Details Imidazole compounds and their use as transglutaminase inhibitors Imidazole compounds and their use as transglutaminase inhibitors

1991-04-29

1992-03-24

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514398, 514258, 514161, 514 56, 514 2, 514822, A61K 37547, A01N 4352, A01N 4350, A01N 4300

Patent

active

050987070

ABSTRACT:
Compositions useful for thrombolytic therapy comprising a plasminogen activator such as tPA or streptokinase together with an imidazolium salt having the formula ##STR1## in a pharmaceutically acceptable carrier and methods for inhibiting hard clot formation or supplementing fibrinolytic therapy are described. The imidazolium salt also may be used with a platelet aggregation inhibitor or anticoagulant.

REFERENCES:
patent: 4182769 (1980-01-01), Cherkofsky
patent: 4814329 (1989-03-01), Harsanyi

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