Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-13
2006-06-13
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S341000, C514S397000, C546S275100, C548S311400, C548S338500
Reexamination Certificate
active
07060721
ABSTRACT:
Imidazole compounds represented by general formula (I):wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.
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W. J. Coates, et al., J. Med. Chem., vol. 36, No. 10, pp. 1987-1392, “Cyclic Nucleotide Phosphodiesterase Inhibiton by Imidazopyridines: Analogues of Sulmazole and Isomazole as Inhibitors of the cGMP Specific Phosphodiesterase”, 1993.
S. J. Lee, et al., J. Med. Chem., vol. 38, No. 18, pp. 3547-3557, “Discovery of Potent Cyclic GMP Phosphodiesterase Inhibitors. 2-Pyridyl- and 2-Imidazolylquinazolines Possessing Cyclic GMP Phosphodiesterase and Thromboxane Synthesis Inhibitory Activities”, 1995.
Abe Yoshito
Hamashima Hitoshi
Hiramura Takahiro
Imoto Takafumi
Ishibashi Naoki
Fujisawa Pharmaceutical Co. Ltd.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Stockton Laura L.
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