Imidazole compositions useful as inhibitors of protein kinases

Details Imidazole compositions useful as inhibitors of protein kinases Imidazole compositions useful as inhibitors of protein kinases

2007-01-30

2007-01-30

Stockton, Laura L. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S247000

Reexamination Certificate

active

10949027

ABSTRACT:
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.

REFERENCES:
patent: WO 00/62778 (2000-10-01), None
patent: WO 03/022274 (2003-03-01), None
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.
Christensen et al., A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.Cancer Research63(21): 7345-55, 2003.
Jiang et al., Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET,Clinical Cancer Research9(11): 4274-81, 2003.
Abounader et al., Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scather factor/hepatocyte growth factor and c-met expression,Journal of the National Cancer Institute91(18):, 1548-1556, 1999.
Davies et al., Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells,Prostate60: 317-324, 2004.
Matsumoto et al., NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics,Cancer Science94(4): 321-7, 2003.
Brockmann et al., Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4,Clinical Cancer Research9(12): 4578-85, 2003.
Wen et al., Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice,Cancer Gene Therapy2004: 1-12, 2004.
Malaviya et al., Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′,5′-dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97),Journal Pharmacology and Experimental Therapeutics, 295(3): 912-26, 2000.

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