Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-10-20
2000-07-25
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514300, 514301, 514302, 514310, 514312, 514313, 514401, 514402, 546112, 546114, 546115, 546122, 546143, 546153, 546155, 546156, 546157, 546159, 546183, 5483114, 5483121, 5483315, A61K 3144, A61K 3147, C07D22104, C07D21538
Patent
active
060937270
ABSTRACT:
This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human a, adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease where modulation of the .alpha..sub.2 receptors may be useful. The invention further provides for a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
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Timmermans, P.B.M.W.M. et al., "Characterization of Alpha-adrenoceptor populations. Quantitative relationships between cardiovascular effects initiated at central and peripheral Alpha-adrenoceptors," J. Med. Chem. (1981) 24: 502-507.
Amemiya, Y., et al., "Synthesis and Alpha-Adrenergic Activities of 2- and 4-Substituted Imidazoline and Imidazole Analogues," J. Med. Chem. (1992) 35:750-755.
Hong, S., et al., "A Structure-Activity Relationship Study of Benzylic Modifications of 4-[1-(1-Napththyl)ethyl]-1H-imidazoles on Alpha 1-and Alpha 2-Adrenergic Receptors," J. Med. Chem. (1994) 37: 2328-2333.
Wong, W.C., et al., "Design and Synthesis of Alpha 2 Adrenoceptor Agonists," 213th American Chemical Society Meeting, San Francisco, CA, Apr. 13-17, 1997, Abstract No. 023, which was mailed to subscribers Mar. 8, 1997.
Gluchowski Charles
Jeon Yoon T.
Wong Wai C.
Kessinger Ann M.
Shah Mukund J.
Synaptic Pharmaceutical Corporation
White John P.
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