Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-10
1995-03-07
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546207, 546210, 546256, 546276, 548253, 5483147, 5483151, 5483351, 5483415, 5483435, 5483461, 514326, 514341, 514381, 514396, 514397, 514399, 514400, A61K 31415, C07D40114, C07D40302
Patent
active
053958446
ABSTRACT:
Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: ##STR1## These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)me thyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino) ethylcarbonyl]-4-ethyl-2-propyl-1H-imidazole, are useful as antihypertensive agents.
REFERENCES:
patent: 5138069 (1992-08-01), Carini
patent: 5217882 (1993-06-01), Chen
patent: 5218125 (1993-06-01), Chen et al.
P. C. Wong, et al., Cardiovascular Drug Reviews 1991; 9:317-339; Trends in Endocrinol. Metal. 1992; 3:211-217).
Duncia John J. V.
Ensinger Carol L.
Olson Richard E.
Quan Mimi L.
Santella III Joseph B.
Davis Zinna N.
Ivy C. Warren
The Du Pont Merck Pharmaceutical Company
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