Imidazole-5-carboxylic acid derivatives, the preparation...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S253000

Reexamination Certificate

active

07858651

ABSTRACT:
The invention discloses imidazole-5-carboxylic acid derivatives, and their preparation methods. The derivatives of the invention are Angiotensin II receptor antagonists with angiotensin II antagonistic activity and antihypertensive activity, and thereby can be used as a therapeutical agent to treat hypertension.

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patent: WO 2005/011646 (2005-02-01), None
patent: WO 2005/023182 (2005-03-01), None
Byrn et al. Solid-State Chemistry of Drugs, 2d, Chapter 11 Hydrates and Solvates, 233-247 (1999).
Morissette et al. Adv. Drug Delivery Rev. 56, 275-300 (2004).
A.M. Rouhi, Chem. & Eng. News, Feb. 24, 2003, 81(8), 32-35.
Drugs of the Future, 1996, vol. 21, No. 2, P139-142, Mealy, N. 35 al., “Elisartan Potassium. Antihypertensive angiotensin II antagonist. HN-6502 1”.
Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 1, P69-74, Elizabeth M. Naylor et al., “Potent Imidazole Angiotensin II Antagonists: Acyl Sulfonamides and Acyl Sulfamides as Tetrazole Replacements”, (1994).

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