Imidazol-1-ylmethyl pyridazine derivatives

Details Imidazol-1-ylmethyl pyridazine derivatives Imidazol-1-ylmethyl pyridazine derivatives

2006-10-17

2006-10-17

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252020, C514S252030, C544S114000, C544S121000, C544S122000, C544S238000

Reexamination Certificate

active

07122546

ABSTRACT:
The invention provides imidazol-1-ylmethyl pyridazine derivatives of the formula:that bind to GABAAreceptors. In the above formula, R1, R2R3, R4, R5, R6and Ar are defined herein. Such compounds may be used to modulate ligand binding to GABAAreceptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAAreceptors (e.g., receptor localization studies).

REFERENCES:
patent: 2003/0220348 (2003-11-01), Xie et al.
patent: PCT/US04/13778 (2004-05-01), None
patent: WO 04/041808 (2004-05-01), None
Damasio, Alzheimer's Disease and Related Dementias, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1992-1996, 1996.
U.S. Appl. No. 60/490,006, filed Jul. 25, 2003, Xie et al.
Drug Evaluations Annual 1991 (American Medical Association), pp. 202-210 and 262.

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