Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-03-12
1983-03-22
Daus, Donald G.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602456, C07D48704
Patent
active
043775233
ABSTRACT:
Novel Imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of organic substituents. An especially preferred genus included within the purview of the invention encompasses a compound of the formula ##STR1## wherein R.sub.1 is hydrogen and lower alkyl preferably methyl; R.sub.3 and R.sub.5 are hydrogen; R.sub.4 is hydrogen, nitro and halogen, most preferably, chlorine, and in a most preferred embodiment when positioned on the fused benzo portion of the imidazobenzodiazepine is in the 8-position thereof, R.sub.6 is phenyl or halo, nitro, or lower alkyl-substituted phenyl, preferably, halo, with fluorine being the preferred halogen, the substituted fluoro being positioned in the 2-position of the phenyl moiety and R.sub.2 is hydrogen and lower alkyl.
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Fryer, et al., J. Heterocyclic Chemistry, vol. 15, pp. 619-624, (06/78).
Fryer Rodney I.
Walser Armin
Daus Donald G.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Rivers Diana G.
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