Imidazobenzodiazepines

Details Imidazobenzodiazepines Imidazobenzodiazepines

1980-04-11

1981-02-10

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424273R, C07D48704

Patent

active

042500958

ABSTRACT:
A multistep process is presented for the preparation of imidazobenzodiazepines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, Y is selected from the group consisting of hydrogen, halogen and trifluoromethyl and R.sub.1 is selected from the group consisting of hydrogen, lower alkyl and aryl.
Also presented are novel intermediates utilized in the process.
The end products are useful as sedatives, anxiolytics, muscle relaxants and anticonvulsants.
The end products are especially useful in intravenous compositions for use in preoperative anesthesia.

REFERENCES:
patent: 3763179 (1973-10-01), Gall
patent: 3852461 (1974-12-01), Hester
patent: 3927016 (1975-12-01), Hester et al.
patent: 4146722 (1979-03-01), Walser et al.
patent: 4194049 (1980-03-01), Field et al.
Fryer et al., J. Org. Chem., vol. 43, pp. 4480-4484, (1978).

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