Imidazo-triazine derivatives as ligands for gaba receptors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S184000

Reexamination Certificate

active

07005431

ABSTRACT:
A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAAreceptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

REFERENCES:
patent: 6617326 (2003-09-01), Carling et al.
patent: 6696444 (2004-02-01), Carling et al.
patent: WO 00 23449 (2000-04-01), None
patent: WO 01 77111 (2001-10-01), None
Scott et al. Prog. Med. Chem. 36: 169-200,1999.

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