Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-18
2007-09-18
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S259310, C514S259300, C544S263000, C544S281000, C544S282000
Reexamination Certificate
active
10898690
ABSTRACT:
Compounds of Formula Iare provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAAreceptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAAreceptors (e.g., receptor localization studies).
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Chenard Bertrand L.
Gao Yang
Han Bingsong
Maynard George
Shaw Kenneth
Berch Mark L.
Russett Mark D.
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