Imidazo-pyrimidine derivatives as ligands for GABA receptors

Details Imidazo-pyrimidine derivatives as ligands for GABA receptors Imidazo-pyrimidine derivatives as ligands for GABA receptors

2006-04-18

2006-04-18

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S252010, C514S234200, C514S255050, C544S282000, C544S122000, C544S238000

Reexamination Certificate

active

07030128

ABSTRACT:
A class of imidazo[1,2-α]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABAAreceptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

REFERENCES:
patent: 5922725 (1999-07-01), Teuber et al.
patent: WO 99 19323 (1999-04-01), None
patent: WO 01 64674 (2001-09-01), None
Martin I. L. et al: “Benzodiazepine Recognition Site Ligands and Gabaa Receptors” Expert Opinion on Therapeutic Patents, Ashley Publications, GB, vol. 9, No. 10, 1999, pp. 1347-1358.
Tully W. R. et al: “General Approach Leading to the Development of Imidazoquinoline andimidazopyrimidine Benzodiazepine Receptor Ligands” Drug Development Research, New York, NY. US, vol. 22, 1991, pp. 299-308.

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