Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-10-09
2007-10-09
Seaman, Margaret D. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S300000
Reexamination Certificate
active
10512984
ABSTRACT:
A class of 8-fluoro-3-phenylimidazo[1,2-α]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a —NH— or —OCH2— linkage, being selective ligands for GABAAreceptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
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Bordi et al., “Group I metabotropic glutamate receptors: implications for brain diseases”, Progress in Neurobiology, 1999, vol. 59, pp. 55-79.
Hand et al., “Imidazo[1,2-a] pyridine 1-Oxide. Synthesis and chemistry of a novel type of N-oxide”, Journal of Organic Chemistry, 1978, vol. 43, pp. 658-663.
Goodacre Simon Charles
Hallett David James
Humphries Alexander Charles
Jones Philip
Kelly Sarah Margaret
Krovatin William
Merck Sharp & Dohme Limited
Rahmani Niloofar
Seaman Margaret D.
Thies J. Eric
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