Imidazo-pyrazine derivatives as ligands for GABA receptors

Details Imidazo-pyrazine derivatives as ligands for GABA receptors Imidazo-pyrazine derivatives as ligands for GABA receptors

2005-07-05

2005-07-05

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S350000

Reexamination Certificate

active

06914063

ABSTRACT:
A class of imidazo[1,2-α]pyrazine analogues substituted in the 3-position by a substituted phenyl ring, being selective ligands for GABAAreceptors which interact more favourably with the α2 and/or α3 subunit than with the α1 subunit, are accordingly of benefit in the treatment and/or prevention of a variety of disorders of the central nervous system, including anxiety and convulsions, with a reduced propensity to cause sedation.

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patent: WO 200285903 (2002-10-01), None
X. Zhao, R. Zhang: “A novel approach to the synthesis of 1-substituted-3, 6-diaryl-imiadazo[1,5-b]pyr idazines”, Synthetic Communications, vol. 25, No. 20, 1995, pp. 3271-3286.

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