Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-09-21
2000-12-12
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514825, 514803, 546 84, 546 86, 546 87, 546144, 546177, A01N 4342, C07D47100
Patent
active
061599859
ABSTRACT:
The subject invention involves compounds having the structure: wherein the C.sub..alpha. --N.sub..beta. and C.sub.5 -C.sub.6 bonds are independently single or double bonds, R1 is selected from alkyl, aryl, and heterocycle; R2-R13 are independently selected from hydrogen and other substituents; and pharmaceutically-acceptable salts thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases and disorders using such compounds.
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Fox et al., "Mechanism of Inhibition of Sodium--and Potassium-Dependent Adenosine Triphosphatase by the Isoquinoline Derivative BIIA: A Specific Interaction With Sodium Activation", Biochemical Pharmacology, 30 (1981) pp. 611-617.
Zolyomi et al., "Potential Drugs Labelled with .sup.14 C. I. The Synthesis of 3-Benzylamino-5,6-dihydro-8,9-dimethoxy-imidazo[5,1-a]lsoquinoline hydrochloride", J. of Labelled Compounds and Radiopharmaceuticals, XVIII (1980) pp. 813-822.
Borchard et al., "Characterization of Antiarrhythmic Drugs by Alternating Current Induced Arrhythmias in Isolated Heart Tissues", Arch. Int. Pharmacodyn., 256 (1982) pp. 253-268.
Fulop et al., "A 3-Benzilamino-5,6-dihidro-8,9-dimetoxi-imidazo-(5,1-a)-izokinolin-hidroklo rid es Intermedierjei Negyszoghullamu Polarografias Vizsgalata", Magyar Kemiai Folyoirat, 89 (1983) pp. 293-297.
Liu Song
Pong Schwe Fang
Portlock David Edward
Clark Karen F.
Covington Raymond
Graff Milton B.
Kight John
The Procter & Gamble & Company
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