Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S083000, C544S060000, C544S126000, C544S361000, C540S575000, C540S599000, C514S218000, C514S228500, C514S212010, C514S232800, C514S253030, C514S254080

Reexamination Certificate

active

10848412

ABSTRACT:
The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I),wherein R1, R2, R3, R4, R5and R6are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

REFERENCES:
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patent: WO 03/080112 (2003-10-01), None
patent: WO 03/080114 (2003-10-01), None
patent: WO 01/00587 (2004-01-01), None
Thomas et al., Halogeno-1,2,5-thiadiazolopyridines and 1,2, 5-selenadiazolopyridines. Heterocycles, vol. 20, No. 6, pp. 1043-1048, 1983.
Burke et al., “BMS-345541 is a highly selective inhibitor of IkB kinase that binds at an allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice,” J. Biolog. Chem., Jan. 17, 2003, vol. 278, No. 3, pp. 1450-1456.

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