Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-04-29
1987-12-29
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514287, 546 82, 546 64, 544126, 544361, 534802, A61K 31415, C07D47104
Patent
active
047161680
ABSTRACT:
The present invention involves compounds of the class of imidazo[4,5-f]quinolines and methods for enhancing the immune response system of mammals which comprises systemically administering to mammals having a depressed immune function an effective but nontoxic amount of a composition comprising such a compound.
REFERENCES:
patent: 3868378 (1975-02-01), Spencer et al.
patent: 3878206 (1975-04-01), Spencer et al.
patent: 3919238 (1975-11-01), Spencer et al.
Goodman and Gilman. The Pharmacological Basis of Therapeutics 6th ed., p. 28.
Alaimo, R. J., C. F. Spencer, J. B. Sheffer, R. J. Storrin, C. J. Hatton and R. E. Kohls, "Imidazol[4,5-f]Quinolines, 4, Synthesis and Anthelmintic Activity of a Series of Imidazo[4,5-f]Quinolin-9-ols", Journal of Medicinal Chemistry, vol. 21, No. 3, (1978), pp. 298-300.
Spencer, C. F., H. R. Snyder, Jr., H. A. Burch and C. J. Hatton, "Imidazo[4,5-f]Quinolines. 2. A Series of 9-(Substituted Amino)Imidazo[4,5-f]Quinolines as Antitapeworm Agents", Journal of Medicinal Chemistry, vol. 20, No. 6, (1977), pp. 829-833.
Snyder, H. R., Jr., C. F. Spencer and R. Freedman, "Imidazo[4,5-f]Quinolines III: Antibacterial 7-Methyl-9-(substituted Arylamino)Imidazo[4,5.f]Quinolines", Journal of Phamaceutical Sciences,vol. 66, No. 8 (Aug., 1977), pp. 1204-1206.
Ishiwata, S. and Y. Shiokawa,"Synthesis of Benzimidazoles and Related Compounds. II. Synthesis of 3H-Imidazo[4,5-f]- and 1H-Imidazo[5,4-g]quinolines", Chemical Pharmaceutical Bulletin, vol. 17, No. 12, (1969), pp. 2455-2460.
Spencer, C. F., H. R. Snyder, Jr. and R. J. Alaimo, "9-Chloro- (or Hydroxy)-2 and/or 7-Substituted-Imidazo[4,5-f]Quinolines (I)", Journal of Heterocyclic Chemistry, vol. 12, No. 6 (Dec., 1975), pp. 1319-1321.
Alaimo Robert J.
Andersen Jon A.
Graff IV Milton B.
Jiles Henry R.
Norwich Eaton Pharmaceuticals, Inc.
Richter J.
Schaeffer Jack D.
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