Imidazo[4,5-b]pyridyl quinolone cardiac stimulants

Details Imidazo[4,5-b]pyridyl quinolone cardiac stimulants Imidazo[4,5-b]pyridyl quinolone cardiac stimulants

1988-04-21

1990-02-06

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544237, 546118, 546141, 546157, 546158, A61K 3147, C07D47104

Patent

active

048988723

ABSTRACT:
A series of novel heterobicyclic substituted 2-(1H)-quinolone compounds have been prepared, including the 3,4-dihydro derivatives thereof, wherein the heterobicyclic ring moiety is an optionally-substituted indolyl, phthalizinyl, benzimidazolyl, imidazopyridinyl, quinolinyl or isoquinolinyl group attached by an nitrogen or carbon atom of said group to the 6-position of the quinolone ring. The optional substituent is a C.sub.1 -C.sub.14 alkyl group located on either of the two heterobicyclic rings and/or an oxo group situated on the heterocyclic portion of said heterobicyclic ring system. These particular compounds are useful in therapy as cardiac stimulants and therefore, are of value in the treatment of various cardiac conditions. 6-{1(H)-Imidazo[4,5-b]pyridin-6-yl}-8-methyl-2-(1H)-quinolone represents a typical and preferred member compound. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 4710507 (1987-12-01), Campbell et al.
patent: 4728653 (1988-03-01), Campbell et al.
patent: 4728654 (1988-03-01), Campbell et al.
patent: 4740513 (1988-04-01), Campbell et al.

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