Imidazo[4,5-b]pyridine derivatives as cardiovascular agents

Details Imidazo[4,5-b]pyridine derivatives as cardiovascular agents Imidazo[4,5-b]pyridine derivatives as cardiovascular agents

1989-09-12

1990-12-11

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 24, 514293, 514303, 546256, 546271, 546118, A61K 3170, A61K 3144, C07H 1700, C07D40100

Patent

active

049771442

ABSTRACT:
Disclosed are the compounds of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl or aryl-lower alkyl; R.sub.1 represents hydrogen, lower alkyl, C.sub.3 -C.sub.7 -alkenyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, or optionally lower alkyl substituted (C.sub.3 -C.sub.7 -cycloalkyl, bicycloheptyl, bicycloheptenyl, adamantyl, tetrahydropyranyl or tetrahydrothiopyranyl)-lower alkyl, or diaryl-lower alkyl; R.sub.2 represents hydrogen or lower alkyl; R.sub.3 represents hydroxymethyl or --CONHR.sub.4 in which R.sub.4 represents hydrogen, lower alkyl, aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl or hydroxy-lower alkyl; pharmaceutically acceptable ester derivatives thereof in which one or more of the hydroxy groups are esterified in form of a pharmaceutically acceptable ester; and pharmaceutically acceptable salts thereof; methods of preparation; pharmaceutical compositions; and their use as adenosine-2 agonists in mammals.

REFERENCES:
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patent: 4276293 (1981-06-01), Lesher et al.
patent: 4714764 (1987-12-01), Sato et al.
patent: 4780452 (1988-10-01), Krenitsky et al.
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J. Heterocyclic Chem. 15, 839 (1978).
Chem. Abstracts 105, 38047v (1986).
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