Imidazo[2, 1-b]-1,3,4-thiadiazole sulfonamides

Details Imidazo[2, 1-b]-1,3,4-thiadiazole sulfonamides Imidazo[2, 1-b]-1,3,4-thiadiazole sulfonamides

2006-04-05

2010-06-22

Tran, S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C424S451000, C424S464000, C514S362000, C514S363000, C514S364000

Reexamination Certificate

active

07741349

ABSTRACT:
This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:

REFERENCES:
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patent: 2002/0052514 (2002-05-01), Hamilton et al.
patent: 1 464 259 (1974-10-01), None
Barnish et al. “Cerebrovasodilatation Through Selective Inhibition of the Enzyme Carbonic Anhydrase 2 Imidazo[2,1-b]thiadizaole and Imidazo[2,1-b]thiazolesulfonamides”, J. Med. Chem 1980, 23:117-121.
Gadad et al. “Synthesis and Biological Evaluation of 5-Formyl-6-arylimidazo(2,1-b)-1,3,4-thiadiazole-2-N-(dimethylaminomethiono)sulfonamides as Antitumor Agents”, Arzneim.-Forsch./Drug Res., 49(II), NR. 10:858-863 (1999).
Scozzafava, A. and Supuran, C.T., “Complexes with Biologically Active Ligands. Part 101Inhibition of Carbonic Anhydrase Isozymes I and II with Metal Complexes of Imidazo[2,1-b]-1,3,4-Thiadiazole-2-Sulfonamide,” XP-002232873, vol. 4(1): 19-26 (1997).
Barnish, Ian T., et al., “Cerebrovasodilatation Through Selective Inhibition of the Enzyme Carbonic Anhydrase. 2. Imidazo[2,1-b]thiadiazole and Imidazo[2,1-b]thiazolesulfonamides,”J. Med. Chem., 23: 117-121 (1980).
Khazi, Imtiyaz A.M., et al., “Synthesis, Anticonvulsant and Analgesic Activities of Some 6-Substituted Imidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamides and Their 5-Bromo Derivatives,”ArzneimForsch Drug Res. (XP-002232875), 46: 949-952 (1996).
Conroy, Curtis W., et al., “The Nonenzymatic Displacement of the Sulfamoyl Group From Different Classes of Aromatic Compounds by Glutathione and Cysteine,”Drug Metabolism and Disposition(XP009006657), 12(5): 614-618 (1984).
Gadad, Andanappa K., et al., “Synthesis and Antibacterial Activity of Some 5-Guanylhydrazone/thiocyanato6-arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide Derivatives,”Eur. J. Med. Chem., 35: 853-857 (2000).
Gadad, Andanappa K., et al., “Synthesis and Biological Evaluation of 5-Formyl-6-arylimidazo(2,1-b)-1,3,4- thiadiazole-2-N-(dimethyl-aminomethino)sulfonamides as Antitumor Agents,”Arzneim.-Forsch./Drug Res., 49(11), Nr. 10: 858-863 (1999).
Supuran, C.T., “Metal Complexes of 1,3,4-Thiadiazole-2,5-Disulfonamide Are Strong Dual Carbonic Anhydrase Inhibitors, Although the Ligand Possesses Very Weak Such Properties,” XP-1002232877,vol. 2(6): 331-336 (1995).

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