Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides

Details Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides

2007-06-12

2007-06-12

Tran, Susan (Department: 1615)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S362000, C424S451000, C424S464000

Reexamination Certificate

active

10498548

ABSTRACT:
This invention relates to compounds of Formula (I) and the use of compounds of Formula (I) as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.

REFERENCES:
patent: 5604202 (1997-02-01), Kessler et al.
patent: 1 464 259 (1977-02-01), None
Scozzafava, A. and Supuran, C.T., “Complexes with Biologically Active Ligands. Part 101Inhibition of Carbonic Anhydrase Isozymes I and II with Metal Complexes of Imidazo[2,1-b]-1,3,4-Thiadiazole-2-Sulfonamide,” XP-002232873, vol. 4(1): 19-26 (1997).
Barnish, Ian T., et al., “Cerebrovasodilatation Through Selective Inhibition of the Enzyme Carbonic Anhydrase. 2. Imidazo[2,1-b]thiadiazole and Imidazo[2,1-b]thiazolesulfonamides,”J. Med. Chem.,23: 117-121 (1980).
Khazi, Imtiyaz A.M., et al., “Synthesis, Anticonvulsant and Analgesic Activities of Some 6-Substituted Imidazo(2,1-b)-1,3,4-thiadiazole-2-sulfonamides and Their 5-Bromo Derivatives,”ArzneimForsch Drug Res.(XP-002232875), 46:949-952 (1996).
Conroy, Curtis W., et al., “The Nonenzymatic Displacement of the Sulfamoyl Group From Different Classes of Aromatic Compounds by Glutathione and Cysteine,”Drug Metabolism and Disposition(XP009006657), 12(5): 614-618 (1984).
Gadad, Andanappa K., et al., “Synthesis and Antibacterial Activity of Some 5-Guanylhydrazone/thiocyanato-6-arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide Derivatives,”Eur. J. Med. Chem.,35: 853-857 (2000).
Gadad, Andanappa K., et al., “Synthesis and Biological Evaluation of 5-Formyl-6-arylimidazo(2,1-b)-1,3,4-thiadiazole-2-N-(dimethyl-aminomethino)sulfonamides as Antitumor Agents,”Arzneim.-Forsch./Drug Res.,49(II), Nr. 10: 858-863 (1999).
Supuran, C.T., “Metal Complexes of 1,3,4-Thiadiazole-2,5-Disulfonamide Are Strong Dual Carbonic Anhydrase Inhibitors, Although the Ligand Possesses Very Weak Such Properties,” XP-1002232877, vol. 2(6): 331-336 (1995).

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