Imidazo(1,5-a)pyrimidine derivatives and their use as antimycoti

Details Imidazo(1,5-a)pyrimidine derivatives and their use as antimycoti Imidazo(1,5-a)pyrimidine derivatives and their use as antimycoti

1984-07-10

1987-03-10

Lesmes, George F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544117, C07D48704, A61K 31505

Patent

active

046491988

ABSTRACT:
Imidazo [1,5-a] pyrimidine derivatives of the formula (I) exhibit antifungal properties: ##STR1## wherein X.sub.1 and X.sub.2 are selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxy group, an amino or substituted amino group, an alkoxy group, an alkylthio group, an alkylsulfinyl group and an alkylsulfonyl group; R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group and an aralkyl group.
Compound (I) are prepared by reacting the corresponding .alpha.-acylamino-alkylpyrimidines with condensing agents to form chlorine-substituted imidazo [1,5-a] pyrimidines, then replacing one or both chlorine atoms in the pyrimidine ring with other substituents, if necessary.

REFERENCES:
patent: 3923808 (1975-12-01), Van Gelder et al.
patent: 4178449 (1979-12-01), Dusza et al.
patent: 4236005 (1980-11-01), Dusza et al.
patent: 4408047 (1983-10-01), Baldwin et al.
Guerret, P. et al., Chemical Abstract 77:125679z (1972).

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