Imidazo[1,5-a]pyridine derivatives and methods for treating...

Details Imidazo[1,5-a]pyridine derivatives and methods for treating... Imidazo[1,5-a]pyridine derivatives and methods for treating...

2007-05-29

2007-05-29

Seaman, Margaret D. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10534631

ABSTRACT:
Compounds of the formula (I)provide pharmacological agents which are inhibitors of the P450 enzyme, aldosterone synthase, and thus may be employed for the treatment of aldosterone mediated conditions. Accordingly, the compounds of formula (I) may be employed for prevention, delay of progression, or treatment of hypokalemia, hypertension, congestive heart failure, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, increased formation of collagen, fibrosis and remodeling following hypertension and endothelial dysfunction. Preferred are the compounds of formula (I) which are selective inhibitors of aldosterone synthase devoid of undesirable side effects due to general inhibition of cytochrome P450 enzymes.

REFERENCES:
patent: 4588732 (1986-05-01), Browne
patent: 4617307 (1986-10-01), Browne
patent: 4889861 (1989-12-01), Browne
patent: 5428160 (1995-06-01), Browne
patent: 5529992 (1996-06-01), Weber
patent: 6037349 (2000-03-01), Sombroek et al.
patent: 6150347 (2002-11-01), Weber
patent: 09071586 (2002-11-01), None
patent: WO 01/27107 (2002-11-01), None
Browne, L.J. et al., “Fadrozole Hydrochloride: A Potent, Selective, Nonsteroidal Inhibitor of Aromatase for the Treatment of Estrogen-Dependent Disease,” J. Med. Chem. vol. 34, 1991, pp. 725-736, (1991).

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