Imidazo (1,2-B) isoquinoline derivatives

Details Imidazo (1,2-B) isoquinoline derivatives Imidazo (1,2-B) isoquinoline derivatives

1975-10-31

1977-07-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260283S, 260283SA, 260287CF, 260287D, 260288CF, 260288D, 260289B, C07D47104, A61K 3147

Patent

active

040354997

ABSTRACT:
5,10-Dihydro-imidazo(1,2b)isoquinolines substituted in the 2- and/or 3-position(s) by an aromatic group have analgesic, anti-inflammatory or anti-pyretic activity. Except for 2-phenyl-5,10-dihydroimidazo(1,2b)isoquinoline, they are believed to be novel compounds. They can be prepared in manner known per se by heating a 2-acylmethyl isoquinolinium salt with an ammonium salt of an organic acid or by reaction of a 3-amino-1,4-dihydroisoquinoline with an .alpha.-halogenocarbonyl compound.

REFERENCES:
burger; Medicinal Chemistry 2nd Edition, (1960), p. 42,497; 3rd Edition (1970) p. 1588.
Cookson et al; J. Chem. Soc., Chem Comm., (1974) p. 911-912.
Krohnke et al; Chem. Ber. vol. 95, (1962) p. 1128.

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