Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents

Details Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents

1986-02-07

1987-06-23

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 84, 546 70, 514285, 544125, 544126, 544361, A61K 31395, C07D47104, C07D41114, C07D40114

Patent

active

046753230

ABSTRACT:
Compounds which are imidazo[1,2-a]quinoline derivatives of general formula (I) ##STR1## in which X is hydrogen, halogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, (C.sub.1-4) alkylthio, methylsulphonyl, amino, (C.sub.1-4)alkylamino, di-(C.sub.1-4)alkylamino, nitro or trifluoromethyl, Y is hydrogen, halogen or methyl in position 6, 7 or 8, R.sub.1 and R.sub.2, which may be the same or different, are hydrogen or (C.sub.1-6) alkyl, or R.sub.1 and R.sub.2 together form a tetramethylene, pentamethylene, 3-methyl-3-azapentamethylene, 3-ethoxycarbonyl-3-azapentamethylene group, and A and B both are hydrogen or together form a carbon-carbon bond, and their pharmacologically acceptable acid addition salts have anxiolytic, sleep-inducing, hypnotic, anticonvulsant, analgesic and anti-ulcer properties.

REFERENCES:
patent: 4387098 (1983-06-01), Barnes et al.
Goodman et al., The Pharmacological Basis of Therapeutics, 6 Ed., p. 28.

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