Imidazo(1,2-a)pyrimidines and their salts useful for treating an

Details Imidazo(1,2-a)pyrimidines and their salts useful for treating an Imidazo(1,2-a)pyrimidines and their salts useful for treating an

1983-08-24

1985-07-30

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544281, C07D48704, A61K 31505

Patent

active

045322430

ABSTRACT:
Novel imidazo[1,2-a]pyrimidines of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 12 carbon atoms, aryl of 6 to 12 carbon atoms, thienyl and pyridyl, each of said group being optionally substituted with at least one member of the group consisting of halogen, alkyl of 1 to 5 carbon atoms, alkoxy and alkylthio of 1 to 5 carbon atoms, trifluoromethyl, amino, alkylamino of 1 to 5 alkyl carbon atoms and dialkylamino with alkyl of 1 to 5 carbons atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 12 carbon atoms, benzyl and phenethyl, or taken together form alkylene of 3 to 5 carbon atoms, each of said groups being optionally substituted with at least one member of the group consisting of halogen, alkyl of 1 to 5 carbon atoms, alkoxy and alkylthio of 1 to 5 carbon atoms, trifluoromethyl, amino, alkylamino of 1 to 5 alkyl carbon atoms and dialkylamino with alkyls of 1 to 5 carbon atoms, X is selected from the group consisting of oxygen and sulfur and R.sub.3 is alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, having anxiolytic activity and novel intermediates.

REFERENCES:
patent: 4223031 (1980-09-01), Covington et al.
patent: 4236005 (1980-11-01), Dusza et al.
patent: 4374988 (1983-02-01), Dusza et al.

Affiliated with

Also associated with

Rating

Imidazo(1,2-a)pyrimidines and their salts useful for treating an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazo(1,2-a)pyrimidines and their salts useful for treating an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazo(1,2-a)pyrimidines and their salts useful for treating an will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2373396