Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1994-07-06
1997-05-27
Geist, Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514212, 514300, 514299, 514301, 514396, 514397, 514398, 514399, 540542, 540597, 546 23, 546121, A61K 3144, C07D47104
Patent
active
056332378
ABSTRACT:
A class of imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## and the carboxylic and phosphonic alkyl esters and salts thereof; wherein R.sup.9 is selected from hydrido, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl; wherein each of Y.sub.m and Y.sub.n is a spacer group independently selected methylene and ethylene radicals which may be unsubstituted and from methylene radicals which may be substituted with a group selected from halo, hydroxy and oxo;
REFERENCES:
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4501745 (1985-02-01), Kaplan et al.
patent: 4588732 (1986-05-01), Browne
patent: 4650796 (1987-03-01), George et al.
patent: 4657899 (1987-04-01), Rzeszotarski et al.
patent: 4746653 (1988-05-01), Hutchison et al.
S.M. Rothman et al, Annals of Neurology, vol. 19, No. 2, 105-111 (1986).
M.N. Perkins et al, Neuroscience Lett., 23, 333 (1981).
J. Davies et al, Neuroscience Lett., 21, 77 (1981).
K. Matoba et al, "Structional Modification of Bioactive Compounds II. Synthesis of Aminophosphonic Acids", Chem. Pharm. Bull., 32, (10), 3918-3925 (1984).
D.E. Murphy et al, J. Pharmacol. Exp. Ther., 240, (3), 778-784 (1987).
Adelstein Gilbert W.
Hansen, Jr. Donald W.
Peterson Karen B.
Tsymbalov Sofya
Bulock Joseph W.
G.D. Searle & Co.
Geist Gary
Jones Dwayne C.
Keane J. Timothy
LandOfFree
Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treat does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treat will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2329157