Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-12-09
1994-11-01
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514212, 514300, 540542, 540597, 546 23, 546121, A61K 3144, C07D47104
Patent
active
053607961
ABSTRACT:
A class of imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## and the carboxylic and phosphonic alkyl esters and salts thereof; wherein the substituents are defined herein.
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Adelstein Gilbert W.
Hansen, Jr. Donald W.
Peterson Karen B.
Tsymbalov Sofya
Bulock Joseph W.
G. D. Searle & Co.
Haley Jacqueline
Keane J. Timothy
Morris Patricia L.
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