Imidazo[1,2-a]pyridines having anti-ulcer activity

Details Imidazo[1,2-a]pyridines having anti-ulcer activity Imidazo[1,2-a]pyridines having anti-ulcer activity

1980-10-30

1982-01-19

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546121, A61K 31435, C07D47104

Patent

active

043117023

ABSTRACT:
Imidazo[1,2-a]pyridine of the formula ##STR1## in which R represents H or CH.sub.3 and R.sub.1 represents H or CH.sub.3 which can be used in human therapy as inhibitors of gastric secretion. The compounds are prepared by reacting a methylisothiourea of the formula ##STR2## with methylamine in aqueous solution of dimethyl formamide or in hydroalcoholic solution, at temperatures between 0.degree. and 50.degree. C.

REFERENCES:
Migrdichian, Organic Synthesis, vol. 1, Reinhold Publishing Co., (1957), p. 409.

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