Imidazo[1,2-a] pyridine anxiolytics

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S300000

Reexamination Certificate

active

07148353

ABSTRACT:
Imidazo[1,2-a]pyridines of the formulae I and II:are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A representative compound of the invention is:

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De Clerck, Isabel; Daenens, P., “Development of a radioimmunoassay for the determination of zolpidem in biological samples,”Analyst(Cambridge, United Kingdom) 122(10), 1119-1124 (1997).
George et al., “Imidazopyridines: Towards Novel Hypnotic and Anxiolytic Drugs”,II Farmaco, 46, 277-288 (1991).
Gupta et al., “Quantitative Structure-Activity Relationship Studies on some Nonbenzodiazepine Series of Compounds Acting at the Benzodiazepine Receptor”,Bioorganic&Medicinal Chemistry, 6, 2213-2218 (1998).

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