Imidazo[1,2-A]pyridine and pyrazolo[2,3-A]pyridine derivatives

Details Imidazo[1,2-A]pyridine and pyrazolo[2,3-A]pyridine derivatives Imidazo[1,2-A]pyridine and pyrazolo[2,3-A]pyridine derivatives

2005-02-15

2005-02-15

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S272000, C544S321000, C544S331000

Reexamination Certificate

active

06855719

ABSTRACT:
A compound of formula (I) wherein Ring A is imidazol[1,2a]pyrid-3-yl or pyrazolo[2,3a]pyrid-3-yl; R2is as defined within; m is 0-5; wherein the values of R2may be the same or different; R1is as defined within; n is 0 to 2, wherein the values of R1may be the same or different; Ring B is phenyl or phenyl fused to a C5-7cycloalkyl ring; R3is as defined within; p is 0-4; wherein the values of R3may be the same or different; R4is as defined within; q is 0-2; wherein the values of R4may be the same or different; and wherein p+q≦5; or a pharmaceutically acceptable salt or an in vivo hydrolyzable ester thereof is described. The use of compounds of formula (I) in the inhibition of cell cycle kinases CDK2, CDK4, and CDK6 are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.

REFERENCES:
patent: 4983608 (1991-01-01), Effland et al.
patent: 5516775 (1996-05-01), Zimmermann et al.
patent: 5521184 (1996-05-01), Zimmermann
patent: 5610303 (1997-03-01), Kimura et al.
patent: 5739143 (1998-04-01), Adams et al.
patent: 5859041 (1999-01-01), Liverton et al.
patent: 2231765 (1998-09-01), None
patent: 0 135 472 (1985-03-01), None
patent: 0 363 002 (1990-04-01), None
patent: 0 379 806 (1990-08-01), None
patent: 0 564 409 (1993-10-01), None
patent: 0 945 433 (1999-09-01), None
patent: 0 945 443 (1999-09-01), None
patent: 9118887 (1991-12-01), None
patent: 9220642 (1992-11-01), None
patent: 9509847 (1995-04-01), None
patent: 9509851 (1995-04-01), None
patent: 9509852 (1995-04-01), None
patent: 9509853 (1995-04-01), None
patent: 9515952 (1995-06-01), None
patent: 9605177 (1996-02-01), None
patent: 9628427 (1996-09-01), None
patent: 9640143 (1996-12-01), None
patent: 9719065 (1997-05-01), None
patent: 9735856 (1997-10-01), None
patent: 9740017 (1997-10-01), None
patent: 9744326 (1997-11-01), None
patent: 9747618 (1997-12-01), None
patent: 9811095 (1998-03-01), None
patent: 9816230 (1998-04-01), None
patent: 9818782 (1998-05-01), None
patent: 9825619 (1998-06-01), None
patent: 9833798 (1998-08-01), None
patent: 9841512 (1998-09-01), None
patent: 9854093 (1998-12-01), None
patent: 9856788 (1998-12-01), None
patent: 9901136 (1999-01-01), None
patent: 9932121 (1999-01-01), None
patent: 9918096 (1999-04-01), None
patent: 9918942 (1999-04-01), None
patent: 9931073 (1999-06-01), None
patent: 9941253 (1999-08-01), None
patent: 9942153 (1999-08-01), None
patent: 9950250 (1999-10-01), None
patent: 9950251 (1999-10-01), None
patent: 0012485 (2000-03-01), None
patent: 0012486 (2000-03-01), None
patent: 0017202 (2000-03-01), None
patent: 0017203 (2000-03-01), None
patent: 0021926 (2000-04-01), None
patent: 0025780 (2000-05-01), None
patent: 0026209 (2000-05-01), None
patent: 0039101 (2000-06-01), None
patent: 0044750 (2000-08-01), None
patent: 0049018 (2000-08-01), None
patent: 0053595 (2000-09-01), None
patent: 0055161 (2000-09-01), None
patent: 0059892 (2000-10-01), None
patent: 0078731 (2000-12-01), None
patent: 0129009 (2001-04-01), None
patent: 0130778 (2001-05-01), None
patent: 0137835 (2001-05-01), None
patent: 0147897 (2001-05-01), None
patent: 0147921 (2001-05-01), None
patent: 0160816 (2001-08-01), None
patent: 0164653 (2001-09-01), None
patent: 0164654 (2001-09-01), None
patent: 0164655 (2001-09-01), None
patent: 0164656 (2001-09-01), None
patent: 0172717 (2001-10-01), None
patent: 0204429 (2002-01-01), None
patent: 0220512 (2002-03-01), None
patent: 02066481 (2002-08-01), None
patent: 02096887 (2002-12-01), None
Donnellan et al., FASEB Journal, 13, 773-777, 1999.*
Ghosh, 2,4-Bis(arylamino)-6-methylpyrimidines as an antimicrobial agents, Chemical Abstract No. 97712f, vol. 95, 1981, pp. 648.
Schmidt et al.; “A Convenient Synthesis of 2-substituted 4-Amino-5-pyrimidinecarbonitriles”; J. Heterocycle Chem., 1997, vol. 24, No. 5, pp. 1305-1307.
Zimmeramann et al., “Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)”, Archiv der Pharmazie, de, VCH, Verlagsgesellschaft MBH, Weinheim, 329 (7), 1996, 371-376.
Boschelli et al., “Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receipt Tyrosine Kianse Inhibitors”, J Med. Chem. 41(22), 1998, 4365-4377.
Deady et all, “Reactions of some Quinazoline Compounds with Ethoxymethylenemalonic Acid Deriviatives”, J Heterocycle Chem, 26(1), 1989, pp. 161-168.
El-Kerdawy et al.; 2,4-Bis (Substituted)-5-Nitropyrimidnes of Expected Diuretic Action; Egypt J. Chem. vol. 29, No. 2, 1986, pp. 247-251.
Fiziol Akt Veshchestva, 1975, vol. 7, pp. 68-72.
Ghosh et al.; 2,4-Bis(arylamino)-5-methylpyrimidines as Antimicrobial Agents; ; J. Med. Chem., 1967, vol. 10, No. 5, pp. 974-975.

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