Imaging tracers for early detection and treatment of amyloid...

Details Imaging tracers for early detection and treatment of amyloid... Imaging tracers for early detection and treatment of amyloid...

2008-04-28

2010-12-28

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C424S001850, C424S001890

Reexamination Certificate

active

07858803

ABSTRACT:
The present invention relates to compounds and methods for imaging and treating Alzheimer's disease or an amyloidosis-associated pathological condition that utilize a novel amyloid imaging tracer for detecting amyloid deposits in a subject suffering from these conditions. In certain embodiments, the invention relates to [N-2[18F]fluoropropyl]-2-(4′-(methylamino)-phenyl)-6-hydroxybenzothiazole (F-18MHT) and dimers thereof.

REFERENCES:
patent: 6696039 (2004-02-01), Kung et al.
patent: 2004/0204344 (2004-10-01), Huang
patent: WO-2004/083195 (2004-09-01), None
Siegemund T., et al. “Thioflavins released from nanoparticles target fibrillar amyloid beta in the hippocampus of APP/PS1 transgenic mice” Int J Dev Neurosci. Apr.-May 2006;24(2-3):195-201. Epub Dec 28, 2005.
International Search Report for International Application No. PCT/US2008/061742, mailed Oct. 21, 2008, 4 pages.

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