Imaging tissue sites of inflammation

Details Imaging tissue sites of inflammation Imaging tissue sites of inflammation

1989-06-09

1991-01-22

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 8591, 514 2, A61K 4902, A61K 3700

Patent

active

049869795

ABSTRACT:
The present invention involves method of enhancing the amount of label accumulating at tissue sites of inflammation. Methods of the present invention take advantage of the up-regulation of surface antigenic markers on leukocytes upon activation thereof. A method of imaging utilizing a chemotactic peptide containing an affinity label and a radionuclide label conjugated to leukocytes is taught. Imaging applications of such enhancement are described.

REFERENCES:
patent: 4331646 (1982-05-01), Delaage
patent: 4443426 (1984-04-01), Thakur
patent: 4497791 (1985-02-01), Gamble et al.
patent: 4832940 (1989-05-01), Ege
patent: 4840793 (1989-06-01), Todd, III et al.
Collet et al., "Scintigraphic Detection in Mice of Inflammatory Lesions and Tumors by an Indium-Labelled Monoclonal Antibody Directed Against Mac-1 Antigen", Cancer Immunol. Immunother., 26: 237-242, 1988.

Affiliated with

Also associated with

Rating

Imaging tissue sites of inflammation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imaging tissue sites of inflammation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imaging tissue sites of inflammation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1554154