Imaging regulated protein-protein interactions in cells and...

Details Imaging regulated protein-protein interactions in cells and... Imaging regulated protein-protein interactions in cells and...

2004-08-06

2008-10-28

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving luciferase

C435S007100, C435S007600, C435S007800, C435S189000, C435S320100, C536S023400

Reexamination Certificate

active

07442518

ABSTRACT:
An enhanced firefly luciferase protein fragment complementation assay method is described that produces a robust and broadly applicable bioluminescence signal and demonstrates both modification-independent and phosphorylation-dependent protein interactions in intact living human cells and animals useful as a diagnostic and testing tool in living biologic systems in research and in assays.

REFERENCES:
R. Paulmurugan et al. . “Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies”. Proc Natl Acad Sci. 99(24): 15608-5613 (Nov. 18, 2002).

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