Imaging of objects in turbid media based upon the preservation o

Details Imaging of objects in turbid media based upon the preservation o Imaging of objects in turbid media based upon the preservation o

1997-02-07

2000-07-18

Smith, Ruth S.

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

600475, 600477, 2503413, 356364, 356433, A61B 500

Patent

active

060919833

ABSTRACT:
A method and system for imaging an object in a turbid medium. According to one embodiment, the method involves (a) making the object luminescent by adding to the object a contrast agent of the type that emits at least partially polarized light when appropriately excited with polarized radiation; (b) exciting the luminescent object through the turbid medium with polarized radiation so as to cause luminescent light to be emitted from the luminescent object, the luminescent light initially being at least partially polarized; (c) after the luminescent light has emerged from the turbid medium, the luminescent light consisting of a ballistic component, a snake-like component and a diffuse component, detecting a pair of complementary polarization components of the luminescent light; and (d) forming an image of the object using the pair of complementary polarization components.

REFERENCES:
Demos et al., "Temporal gating in highly scattering media by the degree of optical polarization," Optics Letters, 21(2):161-3 (Jan. 15, 1996).
Demos et al., "Time resolved degree of polarization for human breast tissue," Optics Communications 124:439-42 (Mar. 15, 1996).
Huang et al., "Optical Coherence Tomography," Science, 254:1178-81 (1991).
Yoo et al., "Imaging objects hidden in scattering media using a fluorescence-absorption technique," Optics Letters, 16(16):1252-4 (1991).
Denk et al., "Two-Photon Laser Scanning Fluorescence Microscopy," Science, 248:73-6 (1990).
Masters et al., Ultraviolet confocal fluorescence microscopy of the in vitro cornea: redox metabolic imaging, Applied Optics, 32(4)592-6 (1993).

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