Imaging of macular pigment distributions

Details Imaging of macular pigment distributions Imaging of macular pigment distributions

2009-04-15

2011-12-13

Casler, Brian (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C600S477000, C600S475000, C600S407000, C607S088000, C356S317000, C351S206000, C351S221000

Reexamination Certificate

active

08078267

ABSTRACT:
Macular pigments are measured by spectrally selective lipofuscin detection. Light from a light source that emits light at a selected range of wavelengths that overlap the absorption band of macular carotenoids is directed onto macular tissue of an eye for which macular pigment levels are to be measured. Emitted light is then collected from the macular tissue. The collected light is filtered so that the collected light includes lipofuscin emission from the macular tissue at an excitation wavelength that lies outside the macular pigment absorption range and outside the excitation range of interfering fluorophores. The collected light is quantified at each of a plurality of locations in the macular tissue and the macular pigment levels in the macular tissue are determined from the differing lipofuscin emission intensities in the macula and peripheral retina.

REFERENCES:
patent: 5697373 (1997-12-01), Richards-Kortum et al.
patent: 5873831 (1999-02-01), Bernstein et al.
patent: 6205354 (2001-03-01), Gellermann et al.
patent: 6276798 (2001-08-01), Gil et al.
patent: 6315412 (2001-11-01), Snodderly et al.
patent: 2002/0193948 (2002-12-01), Schweitzer et al.
patent: 2003/0130579 (2003-07-01), McClane et al.
patent: 2005/0010115 (2005-01-01), Bone et al.
Delori, Macular Pigment Density Measured by Autofluorescence spectrometry: comparison with reflectometry and heterochromatic flicker photometry, J. Opt. Soc. Am A/vol. 18, No. 6/Jun. 2001, 1212-1230.
Delori, Age-Related Accumulation and Spatial Distribution of Lipofuscin in RPE on Normal Subjects, Investigative Ophthalmology & Visual Sciences, Jul. 2001, vol. 42, No. 8, 1855-1866.
Delori, Autofluorescence method to measure macular pigment optical densities fluorometry and autofluorescence imaging, Archives of Biochemistry and Biophysics 430 (2004) 156-162.
Delori, Bimodal spatial distribution of macular pigment: evidence of a gender relationship, J. Opt. Soc. Am A/vol. 28, No. 3/Mar. 2006, 521-538.
Framme, Noninvasive Imaging and Monitoring of Retinal Pigment Epithelium Patterns Using Fundus Autofluorescence—Review, Current Medical Imaging Reviews, 2005, I, 89-103.
Van Norren, Measuring Macular Pigment Optical Density with Undilated Pupil in One Second, Poster Presentation Ophthalmic Res. 36 Suppl 1, 117, (2004).
Robson, Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry, Vision Research 43 (2003), 1765-1775.
Robson, Comparison of fundus autofluorescence and minimum-motion measurements of macular pigment distribution profiles derived from identical retinal areas, Perception, 2005, vol. 34, 1029-1034.
Trieschmann, Macular pigment: quantitative analysis on autofluorescence images, Graefe's Arch Clin Exp Opthalmol (2003) 241:1006-1012.

Affiliated with

Also associated with

Rating

Imaging of macular pigment distributions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imaging of macular pigment distributions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imaging of macular pigment distributions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4300104