1989-06-13
1990-07-24
Evans, F. L.
350317, 350318, G02B 520
Patent
active
049431420
ABSTRACT:
A microscope is modified to allow for precise imaging of samples using different filters at different focal planes under computer control. A filter accessory includes a filter disc having bandpass filters. The filter disc may be rotated to move a selected filter into the optical path between a light source and the microscope sample. Adjustment of the image plane of the microscope is controlled by the computer using feedback from a lens position sensor.
REFERENCES:
patent: 3913128 (1975-10-01), Van den Bosch
patent: 3973725 (1976-08-01), Watanabe et al.
patent: 4125828 (1978-11-01), Resnick et al.
patent: 4191940 (1980-03-01), Palicyn et al.
patent: 4364630 (1982-12-01), Hayasaka
patent: 4443108 (1984-04-01), Webster
patent: 4524383 (1985-06-01), de Rooij
patent: 4573195 (1986-02-01), de France
patent: 4661986 (1987-04-01), Adelson
patent: 4744667 (1988-05-01), Fay et al.
F. S. Fay, K. E. Fogarty, J. M. Coggins, Analysis of Molecular Distribution in Single Cells Using a Digital Imaging Microscope, Optical Methods in Cell Physiology, P. Deweer and B. Salzberg, eds., John Wiley & Sons (New York), 1985.
F. S. Fay, K. Fujiwara, D. D. Rees and K. E. Fogarty, Distribution of .alpha.-Actinin in Single Isolated Smooth Muscle Cells, The Journal of Cell Biology, Vol. 96, Mar. 1983, pp. 783-795.
D. A. Williams, K. E. Fogarty, R. Y. Tsien and F. S. Fay, Calcium Gradients in Single Smooth Muscle Cells Revealted by the Digital Imaging Microscope Using Fura-2, Nature, vol. 318, No. 6046, pp. 558-561, Dec. 12, 1985.
Chance et al., "A Time Sharing Fluorometer for the Readout of Intracellular Oxidation-Reduction States of NADH and Flavoprotein", The Review of Scientific Instruments, vol. 42, No. 7, Jul. 1979, pp. 951-957.
Zeidler, "The Fluorescence Microscope," Laboratory Equipment Digest, vol. 12, No. 7, Jul. 1974, pp. 48, 50-54, 56, 57.
Fay Fredric S.
Fogarty Kevin E.
Rodgers Cyril
Evans F. L.
University of Massachusetts Medical Center
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