Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1998-09-03
2000-08-08
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 111, 424 91, 424 165, 127 30, 127 36, 514 23, A61K 5100, A61M 3614
Patent
active
060998229
ABSTRACT:
Disclosed is a composition of matter useful in imaging tissue, the composition comprising a complex formed between technetium (Tc-99m) and 5-thio-D-glucose. Also disclosed is a method of in vivo imaging of acute ischemic tissue and tumors in a mammalian subject comprising delivering into the subject an effective amount of (Tc-99m)-5-thio-D-glucose, and scanning the subject to determine the distribution of the Tc-99m-TG complex in the subject. A method of preparing the composition of matter is also disclosed.
REFERENCES:
patent: 3466361 (1969-09-01), Richards et al.
patent: 4208398 (1980-06-01), Kubiatowicz et al.
U. Abram, et al., "Technetium Mixed-Ligand Complexes Containing Bidentate Phosphines and Monodentate Tiol Ligands. Preparation, in vitro Data and Detection of a Certain Heart Affinity," Appl. Radiat. Isol. 39(5):385-390, 1988.
A.M. Markoe, et al., "Tissue Distribution and Retention of 5-thio-D-glucose in Animal Tumor Models," Canc. Clin. Trials 3(2):155-163, 1980 (Abstract).
K. Ozker, et al., "Tc-99m Labeled 5-thio-D-glucose," J. Nucl. Med. 39(5) :217P, 1998 (Abstract).
Dox et al, The Harper Collins Illustrated Medical Dictionary, pp. 227 (ischemia & ischemic) & 494 (tumor), 1993.
Collier Bert David
Ozker Suleyman Kutlan
Dees Jos,e G.
Jones Dameron
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