Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1998-02-27
1999-12-28
Smith, Ruth S.
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600431, 424 93, 424 933, A61B 5055
Patent
active
060093420
ABSTRACT:
The endothelial integrity of microvessels is disturbed in malignant tumors. We invented a method wherein we used MRI to define tumor microvascular permeabilities and correlated these permeabilities with histologic grade in tumors. Using macromolecular MRI contrast medium, we discovered tumor microvascular permeability values were significantly lower in benign tumors than in carcinomas. In addition, we found that the microvascular permeability values demonstrated a strong correlation with the histologic grade of carcinomas as determined by the Scarff-Bloom-Richardson grading system.
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Brasch Robert C.
Daldrup Heike E.
Shames David M.
Smith Ruth S.
The Regents of the University of California
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