Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2003-07-16
2008-10-07
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C514S634000, C424S001110
Reexamination Certificate
active
07432397
ABSTRACT:
The invention relates to compounds of formula: (I) or a salt or solvate thereof, wherein: R1is —11CH2R5or [18F]—C1-4fluoroalkyl wherein R5is hydrogen or C1-4alkyl; R2is hydrogen or C1-4alkyl; R3is halo; and R4is halo, C1-4alkylthio, or C1-4alkyl; and their use for imaging central nervous system (CNS) receptors.
REFERENCES:
patent: 94/27591 (1994-12-01), None
patent: 95/14461 (1995-06-01), None
Gibbs, Andrew R.; Morimoto, Hiromi; VanBrocklin, Henry F.; Williams, Philip G.; Biegon, Anat. Synthesis of N-(2-chloro-5-methylthiophenyl)-N′-(3-methyl-thiophenyl)-N′-[3H3] methylguanidine Journal of Labelled Compounds and Radiopharmaceuticals (2002), 45 (5), 395-400.
Rikki N. Waterhouse, Filip Dumont, Abida Sultana, Norman Simpson and Marc Laruelle J Label Compd Radiopharm 2002; 45: 955-964.
Donald M Wieland, Thomas J. Mangner, Muthiah N. Inbasekaran, Lawrence E. Brown, and Jiann-long Wu J. Med. Chem. 1984,27,149-155.
Anthony F Shields, Michael M Graham, Susan M. Kozawa, Laura B. Kozell, Jeanne M. Link J Nucl Med 1992; 33:581-584.
Lain-Yen Hu, Junqing Guo, Sharad S Magar, James B Fischer, Kathleen J Burke-Howie and Graham J Durant J Med Chem 1997, 40, 4281-4289.
Chyng-Yann Shiue, Shankar Vallabhahosula, Alfred P Wolf, Stephen L Dewey, Joanna S Fowler, David J Schlyer, Carroll D Arnett and Yi-Guo Zhou Nuclear Medicine and Biology, vol. 24, pp. 145-150, 1997.
J. Owens et.al.: Nuclear Medicine & Biology, vol. 27, No. 6, 2000, pp. 557-564.
A.R. Gibbs, et.al: Journal of Labelled Compounds and Radiopharmaceuticals, vol. 45, No. 5, Apr. 2002 pp. 395-400.
A.A. Wilson, et.al.: J. Med. Chem. vol. 34, No. 6, 1991, pp. 1867-1870.
CAPLUS Abstract Accession No. 2002:370623 & Journal of Labelled Compounds & Radiopharmaceuticals vol. 45, No. 5, 2002, Andrew R Gibbs, et.al, “Synthesis of N-(2-chloro-5-methylthiophenyl)-N′-(3-methylthiophenyl)-N′-[3H3]methylguanidine, {[3H3]CNS-5161]}”, pp. 395-400 [see abstract].
CAPLUS Abstract Accession No. 2002:274772 & British Journal of Clinical Pharmacology vol. 53, No. 3, 2002, MR Walters, et.al, “Early clinical experience with the novel NMDA receptor antagonist CNS 5161”, pp. 305-311 (see abstract).
CAPLUS Abstract Accession No. 2001: 177402 & Biorganic & Medicinal Chemistry Letters vol. 11, No. 4, 2001, S Padmanabhan et.al., Identification and characterization of a potential ischemia-selective N-methyl-d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788, pp. 501-504 (see abstract).
CAPLUS Abstract Accession No. 1998:35396 & Journal of Medicinal Chemistry vol. 40, No. 26, 1997, Lain-Yen Hu, et.al, “Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers”, pp. 4281-4289 (see abstract).
International Search Report for PCT/GB03/03078 dated Oct. 8, 2003.
British Search Report for GB0216621.3 dated Dec. 20, 2002.
Joannes TM Linders, Current Opinion in CPNS Investigation Drugs 1999, pp. 167-170.
Paula M. Bokesch, Anesthesiology, pp. 202-208.
A. Bigeon, et.al., Development of CNS5161 for NMDA Receptor Imaging, J. Nucl. Med. 43 (2002) No. 1447 p. 360P.
Brady Frank
Luthra Sajinder Kaur
Bohlken Craig
Hammersmith Imanet Ltd.
Kumar Shailendra
LandOfFree
Imaging compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imaging compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imaging compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4004299