Radiant energy – Invisible radiant energy responsive electric signalling – With or including a luminophor
Reexamination Certificate
1999-06-18
2001-06-19
Porta, David P. (Department: 2882)
Radiant energy
Invisible radiant energy responsive electric signalling
With or including a luminophor
C250S363020
Reexamination Certificate
active
06249003
ABSTRACT:
BACKGROUND OF THE INVENTION
The present invention relates to medical imaging cameras, and more specifically to imaging systems which include a mechanism for determining emission attenuation to compensate emission images for varying patient densities.
Single photon emission computed tomography (SPECT) examinations are carried out by injecting a dilution marker comprising a compound labeled with a radiopharmaceutical tracer into the body of a patient to be examined. The radiopharmaceutical is a substance that emits photons of gamma radiation at a specific energy level. By choosing a compound that will accumulate in an organ to be imaged, the compound concentration, and hence radiopharmaceutical concentration, can be substantially limited to that organ of interest. Thus measuring the intensity of the gamma rays emitted from the patient, enables identification of organ characteristics and irregularities.
A planar gamma camera is used to measure the intensity of the photon emission. That camera comprises a stand that supports a collimator, a scintillation crystal and a detector consisting of a two dimensional array of photomultiplier tubes (PMTs) in a adjacent to the patient. The collimator typically includes a lead block with tiny holes there through which define preferred photon paths. The scintillation crystal abuts the collimator on a side opposite the patient to absorb photons and emit light each time a photon is absorbed. The PMTs detect the light emitted by the scintillation crystal and respond by generating analog intensity signals corresponding to the energy level of each photon.
A processor receives the PMT signals and processes those having energy levels that are associated with photon emitted by the radiopharmaceutical tracer. The processor digitally stores emission information as a two dimensional array of pixels. The two dimensional array corresponds to the array of PMTs which the pixels forming a histogram of the number of photons of the proper energy levels detected by each PMT. The pixel information is used by the processor to form an emission projection image associated with the specific camera position.
Most gamma camera systems generate a plurality of emission projection images, each taken by positioning the detector parallel to, and at an angle about, a rotation axis. The angle is incremented between views so that the plurality of projection images can be used together to construct pictures of transaxial slices of the body using algorithms and iterative methods that are well known to those skilled in the tomographic arts.
Unfortunately, because different materials are characterized by different attenuation coefficients, photons are attenuated to varying degrees as they pass through various portions of a patient's body. For example, a given thickness of bone typically attenuates a greater percentage of photons than the same thickness of tissue. The organ image is degraded when the different anatomical features attenuate the radiation leaving the body, in effect casting shadows on the projection image. When the projection images taken at many different view angles are used to reconstruct a tomographic picture, these shadows create artifacts in the reconstructed picture.
To compensate for such artifacts a transmission measurement may be made by placing a calibrated radiation source on the opposite side of the patient from the gamma camera and measuring the amount of radiation that passes through the patient. This provides a measurement of how much of the known radiation is attenuated. The transmission radiation source emits gamma rays at a different energy level that is distinguishable from the radiopharmaceutical energy level, thus allowing the gamma camera to separately measure the emission received from each source. However, when imaging a patient using a radiopharmaceutical tracer that has a higher energy than the transmission source, scattered photons from the tracer can be reduced in energy and mistaken for transmission photons. This “crosstalk” contaminates the transmission image.
A previous approach that reduced the crosstalk effects involved “masking”—electronically defining an acceptance window on the detector. Radiological events outside the acceptance window were masked, or rejected, from further processing. The acceptance window moves in correspondence with a scanning transmission line source so that the window instantaneously exposes the area on the detector where transmission events are expected to occur. Although this masking reduces the crosstalk, it does not eliminate the need for some crosstalk correction.
The simplest way to acquire the needed data is to first perform a complete tomographic acquisition which only accepts emission data (i.e. photons at energy levels from the radiopharmaceutical tracer). During this time an image also can be acquired using the transmission energy levels, but with the transmission gamma source inactive. This latter image provides a measurement of the activity that scatters from the tracer and appears in the transmission energy range which then is used to correct crosstalk in the transmission image. A second acquisition is performed during which the transmission source is swept across the detector field of view at each view angle. The transmission events within the transmission energy range and within the mask acceptance range are detected. While this technique provides a simple process for eliminating crosstalk, it requires two rotations of the detector assembly and prolongs the patient's stay in the imaging system. In addition, the method is susceptible to errors resulting from movement of the patient between the two acquisitions.
SUMMARY OF THE INVENTION
A typical medical imaging system, with which the present invention can be used, produces an image from emission of photons at a first energy level from a radiopharmaceutical tracer injected into the patient. The system includes a camera and a line radiation source. The camera has a two dimensional array of radiation detectors arranged in rows and the line radiation source moves across the rows of radiation detectors while emitting photons at a second energy level. An event occurs when a given photon strikes one of the radiation detectors.
The present image compensation method designates at least one row of radiation detectors as an acceptance region of the camera and designating other rows of radiation detectors as a mask region. Each event is categorize as either an emission event, a transmission event or a crosstalk event. Emission events occur when the given photon has an energy level in a range that includes the first energy level and strikes the mask region. An event is catagorize as a transmission event when the given photon has an energy level in a range that includes the second energy level and that event occurs in the acceptance region. Crosstalk events are defined as produced by photon that has an energy level in a range that includes the second energy level and which strikes the camera in the mask region. Information about each emission event, transmission event and crosstalk event is stored in a separate memory area for each type of event.
The acceptance and mask regions are periodically redesignated as the line radiation source moves across the camera's field of view. The dynamically defined regions continue to be used to categorize the events until the line radiation source has traversed the entire field of view of the camera. Thereafter, a corrected transmission image is produced by combining information about transmission events and crosstalk events. In the preferred imaging system the corrected transmission image is used to compensate the emission image which depicts the desired anatomical feature of the patient.
REFERENCES:
patent: 4755679 (1988-07-01), Wong
patent: 5608221 (1997-03-01), Bertelsen et al.
patent: 5936247 (1999-08-01), Lange et al.
patent: 6140649 (2000-10-01), Lonn
patent: 6194724 (2001-02-01), Kaoukab Raji
General Electric Company
Haas George E.
Ho Allen C.
Porta David P.
Quarles & Brady LLP
LandOfFree
Imaging attenuation correction method employing multiple... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imaging attenuation correction method employing multiple..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imaging attenuation correction method employing multiple... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2512755