Imaging and evaluating embryos, oocytes, and stem cells

Surgery – Reproduction and fertilization techniques

Reexamination Certificate

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C600S034000, C600S035000, C435S375000, C435S083000

Reexamination Certificate

active

07963906

ABSTRACT:
Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

REFERENCES:
patent: 2008/0247628 (2008-10-01), Ramsing
patent: WO 2007/144001 (2007-12-01), None
International Search Report issued Nov. 15, 2010 in connection with PCT Appl. No. PCT/US2010/046343.
Fenwick, et al., (2002) “Time from insemination to first cleavage predicts developmental competence of human preimplantation embryos in vitro,” Human Reproduction, 17(2):407-412.
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Lequarre, et al., (2003) “Cell cycle duration at the time of maternal zygotic transition for in vitro produced bovine embryos: effect of oxygen tension and transcription inhibition,” Biology of Reproduction, 69:1707-1713.
Brezinova, et al. (2009) “Evaluation of day one embryo quality and IVF outcome-a comparison of two scoring systems, ”Reproductive Biology and Endocrinology, 7:9-14.
Lewin, et al. (1994) “Embryo growth rate in vitro as an indicator of embryo quality in IVF cycles,” Journal of Assisted Reproduction and Genetics, 11(10):500-503.
Cummins, et al. (1986) “A formula for scoring human embryo growth rates in in vitro fertilization: Its value in predicting pregnancy and in comparison with visual estimates of embryo quality,” Journal of In Vitro Fertilization and Embryo Transfer, 3(5):284-295.
Ramsing and Callesen, (2006) “Automated image analysis quantifies blastomere activity in time-lapse images to detect onset and duration of cell division during embryo development,” Abstracts of the 22ndAnnual Meeting of the ESHRE, Prague, Czech Republic, Jun. 18-21, 2006.
Francsovits, et al., (2006) “Examination of early cleavage and its importance in IVF treatment,” Journal Reproduktionsmed Endokrinol, 3(6):367-372.

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