Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2003-01-10
2008-08-05
Puttlitz, Karl J (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S439000, C562S496000, C560S034000, C560S171000
Reexamination Certificate
active
07408079
ABSTRACT:
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express NAALADase and/or PSMA to which the compounds of the invention have an affinity.
REFERENCES:
patent: 6479470 (2002-11-01), Kozikowski et al.
patent: 6528499 (2003-03-01), Kozikowski et al.
patent: 1 046 627 (2000-10-01), None
patent: WO 98/45256 (1998-10-01), None
patent: WO 00/64911 (2000-11-01), None
patent: WO 01/72958 (2001-10-01), None
patent: WO 02/22627 (2002-03-01), None
Konda et al., “First total synthesis of Mer-N5075A and a diastereomeric mixture of α and β-MAPI, new HIV-I protease inhibitors from a species ofStreptomyces,” Tetrahedron57:4311-4321 (2001).
Kozikowski et al., “Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase),”J. Med. Chem., 44:298-301 (2001).
Peter et al., “Application of (S)-N-(4-Nitrophenoxycarbonyl) phenylalanine Methoxyethyl Ester as a New Chiral Derivatizing Agent for Proteinogenic Amino Acid Analysis by High-Performance Liquid Chromatography,”Chromatogrphia52:821-826 (2000).
Pomper et al., “11C-MCG: Synthesis, Uptake Selectivity and Primate PET of a Probe for Glutamate Carboxypeptidase II (NAALADase),”Molecular Imaging1:96-101 (2002).
Shin-Watanabe et al., “The Structure of β-MAPI, a Novel Proteinase Inhibitor,”Tetrahedron38:1775-1780 (1982).
Umezawa et al., “Structure of Antipain, a new Sakagushi-positive product of streptomyces,”Journal of Antibiotics25:267-270 (1972).
Kozikowski Alan P.
Musachio John L.
Pomper Martin Gilbert
Zhang Jiazhong
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Puttlitz Karl J
Sparks Jonathan M.
The Johns Hopkins University
LandOfFree
Imaging agents and methods of imaging NAALADase or PSMA does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imaging agents and methods of imaging NAALADase or PSMA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imaging agents and methods of imaging NAALADase or PSMA will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4019003