X-ray or gamma ray systems or devices – Specific application – Absorption
Reexamination Certificate
2002-09-30
2003-12-09
Bruce, David V. (Department: 2882)
X-ray or gamma ray systems or devices
Specific application
Absorption
C378S098300
Reexamination Certificate
active
06661869
ABSTRACT:
The present invention relates to methods for reconstructing two and three dimensional images of objects using X-ray image projections and algebraic reconstruction techniques.
BACKGROUND OF THE INVENTION
X-ray imaging is widely used to image internal organs for diagnostic purposes and to assist health practitioners during therapeutic interventions. For example, this technique has found many applications in cardiology including intra ventricular interventional cardiac procedures such as Direct Myocardial Revascularization and electro physiological mapping and ablation.
In order to extract useful structural information from X-ray irradiation of an object, the projections data must often be extensively processed using image reconstruction techniques. Such image reconstruction techniques are well-known in the art and include for example, algorithms known as ART (Algebraic Reconstruction Techniques). A good introduction to these concepts can be found in Principles of Computerized Tomographic Imaging, by Kak and Slaney, IEEE Press, 1988. Using these techniques, X-ray tomographic images can be obtained by irradiating the object to be examined from a multiplicity of directions and processing the information from each of the projections to reconstruct the image of the object.
Image reconstructions based on ART often require many projections from different angles (often more than 100) to obtain good quality images. As a result, acquisition times are long and necessitate the immobilization of the patient for prolonged periods to minimize positional errors. Furthermore, the long acquisition times may be prohibitive for emergency procedures and may reduce the availability of the apparatus.
Methods have been devised to reduce the number of projections required to obtain satisfactory images. One such method is disclosed in U.S. Pat. No. 4,672,651 wherein two X-ray projections of an object are obtained from which an initial image of the object is corrected by a relaxative procedure. More specifically, the shape of the object is modified or corrected in accordance with individual data values in the projection images for the two directions, thereby producing a corrected shape. Eiho et al. (Japanese J. of Soc. of Instrument and Control Engineers Vol. 19 No. 10, Pages 923-936, 1980) disclose a similar method for image reconstruction using two projections. However, these methods are generally limited to ellipsoid objects and require extensive computational time.
A further method has been described in U.S. Pat. No. 5,442,672 that uses two X-ray projections to tomographically reconstruct images of objects in baggages. The method is based on multiplicative algebraic reconstruction techniques (MART) wherein successive slices of the object are projected. This method requires that the value of each pixel in the image intercepted by a given X-ray, be adjusted to the average density of the object along the path of the X-ray. However, the method is somewhat limited by the heterogony of the object's densities which have to be estimated. Accordingly, a number of constraints have to be applied pertaining to the characteristics of the objects such as density and spacial continuity for example. Furthermore, the acquisition of several slices within each projection and their processing for image reconstruction may be time consuming.
In view of the state of the art, it would be desirable to provide a method requiring few projections and rapid computational calculations to effect the correction of the projections data.
SUMMARY OF THE INVENTION
The present invention relates to a method for reconstructing the image of an object using at least two X-ray projections.
According to one aspect of the present invention, there is provided a method of constructing an image of an object using at least two X-ray absorbance profiles. The method comprises the steps of; a) filling the object to be imaged with an X-ray agent, the X-ray agent attenuating X-rays; b) generating at least two one-dimensional X-ray absorbance profiles with respect to a pre-selected plane of the object by irradiating the agent-filled object with X-rays from at least two directions; c) producing a two-dimensional image by back-projecting the above at least two one-dimensional X-ray absorbance profiles; d) transforming the two-dimensional image into a two-dimensional binary image; e) forward-projecting the two-dimensional binary image into at least two one-dimensional projections, wherein the one-dimensional X-ray absorbance profiles and the one-dimensional projections correspond to each other; f) estimating a difference between each X-ray absorbance profile and each corresponding projection; and g) producing a corrected two-dimensional image by normalizing the difference throughout the two-dimensional binary image.
According to another aspect of the present invention, there is provided a method of constructing the image of an object using at least two X-ray absorbance profiles. The method comprises the steps of; a) filling the object to be imaged with an X-ray agent, the X-ray agent attenuating X-rays; b) generating at least two one-dimensional X-ray absorbance profiles by irradiating the age rays from at least two directions, each profile having a plurality of profile elements, each of which corresponds to a certain X-ray path; c) producing a first image by back-projecting the above at least two one-dimensional X-ray absorbance profiles, wherein the first image includes a plurality of picture elements, each picture element having each respective X-ray absorbance value; d) transforming the first image into a binary image; e) forward-projecting the binary image into at least two one-dimensional projections, wherein the one-dimensional X-ray absorbance profiles and projections correspond to each other; f) estimating a difference between each X-ray absorbance profile and each corresponding projection; and g) to produce a corrected image.
According to another aspect of the present invention, there is provided an apparatus for constructing an image of an object using at least two X-ray absorbance profiles. The apparatus comprises the steps of; a) means for filling the object to be imaged with an X-ray agent, the X-ray agent attenuating X-rays; b) means for generating at least two one-dimensional X-ray absorbance profiles with respect to a pre-selected plane of the object by irradiating the agent-filled object with X-rays from at least two directions; c) means for producing a two-dimensional image by back-projecting the above at least two one-dimensional X-ray absorbance profiles; d) means for transforming the two-dimensional image into a two-dimensional binary image; e) means for forward-projecting the two-dimensional binary image into at least two one-dimensional projections, wherein the one-dimensional X-ray absorbance profiles and the one-dimensional projections correspond to each other; f) means for estimating a difference between each X-ray absorbance profile and each corresponding projection; and g) means for producing a corrected two-dimensional image by normalizing the difference throughout the two-dimensional binary image.
According to the present invention is also provided a method for reconstructing an image of an object using at least two single plane X-ray projections, the method comprising the steps of; irradiating said object with X-rays from at least two directions; detecting said X-rays transmitted through said object to define at least two projection mask X-ray absorbance profiles; substantially uniformly filling the object with an X-ray contrast agent; irradiating said contrast agent-filled object with X-rays from at least two directions; detecting said X-rays transmitted through said contrast agent-filled object to define at least two live X-ray projection absorbance profiles; subtracting said mask profiles from said live profiles to define a final absorbance profile for each projection; providing a first image to be corrected; updating said image by setting the absorbance value to 0 for all picture elements having an absorbance below
Bruce David V.
Cedara Software Corp.
Pearne & Gordon LLP
LandOfFree
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