Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-03-28
1999-03-30
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
435 1, 435 23, 435213, 4352401, 530843, 530844, A61K 908
Patent
active
058885293
ABSTRACT:
A method of treating or preventing post-operative ileus in a mammalian subject is disclosed. The method involves administering to the subject, a pharmaceutically effective amount of a compound that is effective in (i) preventing mast cell degranulation, (ii) inhibiting tryptase and chymase, and (iii) antagonizing PAR-2. The treatment is based on the discoveries that proteinase-activated receptor 2 is expressed in colonic muscle cells, and that activation of PAR-2 inhibits colonic motility. The PAR-2 receptor is activated, at least in part, by tryptase and chymase, produced by infiltration and degranulation of mast cells.
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Bunnett Nigel W.
Corvera Carlos U.
Channavajjala Lakshmi
Dehlinger Peter J.
Judge Linda R.
Page Thurman K.
The Regents of the University of California
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