Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-08-21
1998-07-14
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514369, 514445, 514586, 514597, A61K 3147, A61K 31425, A61K 3138, A61K 3117
Patent
active
057804834
ABSTRACT:
This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in treating chemokine mediated diseases wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (Ia) are represented by the structure: ##STR1## wherein interalia, X is oxygen or sulfur;
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Hertzberg Robert Philip
Jurewicz Anthony Joseph
Rutledge, Jr. Melvin Clarence
Veber Daniel Frank
Widdowson Katherine Louisa
Dinner Dara L.
Jarvis William R. A.
Lentz Edward T.
SmithKline Beecham Corporation
Venetianer Stephen
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