IL-7 to stimulate platelet production

Details IL-7 to stimulate platelet production IL-7 to stimulate platelet production

1989-01-17

1991-07-16

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 514 2, 514 8, 514 12, 514 21, 530351, A61K 3702

Patent

active

050323962

ABSTRACT:
Methods for stimulating platelet production in mammals, comprising administration of interleukin-7 (IL-7), are disclosed.

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Kawakita et al., "Apparent Heterogeneity of Human Megakaryocyte Colony- and Thrombopoiesis-Stimulating Factors." Brit. J. Haematol. 52:429-438 (1982).
Hoffman et al., "Assay of an Activity in the Serum of Patients with Disorders of Thrombopoiesis that Stimulates Formation of Megakaryocytic Colonies," New Engl. J. Med. 305:534 (1981).
Messner et al., "The Growth of Large Megakaryocyte Colonies from Human Bone Marrow," J. Cell. Physiol. Suppl. 1:45-51 (1982).
Kimura et al., "Human Megakryocytic Progenitors (CFU-M) Assayed in Methylcellulose: Physical Characteristics and Requirements for Growth," J. Cell. Physiol. 118:87-96 (1984).
Hoffman et al., "Purification and Partial Characterization of a Megakryocyte Colony-Stimulating Factor from Human Plasma," J. Clin. Invest. 75:1174-1182 (1985).
Namen et al. "Stimulation of B-Cell Progenitors by Cloned Murine Interleukin-," Nature 333:571 (1988).
Namen et al., "B Cell Precursor Growth-Promoting Activity," J. Exp. Med., 167:988-1002 (1988).

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